I think a truly "realistic" hard SF RPG, with no restrictions on information technology and automation (whether narrative-based restrictions or simple hand-waving) is at risk of being borderline unplayable. Too many situations solved by drones and AI, too much time spent future-version-of-Googling everything about every person and event the PCs come across, too much emphasis on knowing how current tech works and extrapolating into the future, turning the resident developers and IT staff among the player group into apparent setting masters. Too much tech, basically, and not enough player decisions.
That's why, to me, science fantasy--or more in that direction than the other way--is maybe the better choice for most RPGs. That, or isolating the players in a hard SF setting, meaning they can't look poke through vast equipment lists or have access to the most cutting edge tech, and please never any conversations about how programs or computers "should" work in the future. Scarcity and simplicity are a SF game's best friends, IMO.