My group had a short campaign loosely based on Wreck-It Ralph that worked along those lines. Each PC was a character from a different video game, and we journeyed to other game worlds. It worked fine. (My character was the plucky heroine of a point-and-click mystery adventure game set in the 1930s. Investigative rogue with the equipment reskinned--for example, flashlight, Zippo, and Thermos instead of torch, tinderbox, and waterskin.)