Closest you're likely to get to swinging a big sword with a shield is bastard sword and shield, then slotting Wicked Blade (paragon, MP2) to gain the High Crit property on your basic attacks. This only works well for a class that uses MBAs or has powers that count as one, such as the Slayer or Knight.
Pure damage boosts are uncommon. Besides Weapon Focus, Frostcheese (and similar Divinity feats), and the ever-popular Iron Armbands of Power, there isn't a lot else (there are some, but they're not general-use).