Any particular reason why?
Well, my original idea was to run MiBG as a prologue and get the PCs to level 3 before starting HotDQ, making them more survivable in the raid on Greenest. But the two adventures aren't really connected thematically, and I couldn't see any good ways to bring the dragon-related bonds into MiBG. I also couldn't see a very easy way to send all the PCs to Greenest once the events of MiBG were over. On the whole, I thought that it would feel like what it was--two unrelated adventures tacked onto each other for no particular reason.
For purposes of what you are thinking of doing, the structure of MiBG might be more of a challenge. It's very tightly woven, with pretty much everything put into the service of mounting tension in the plotline, but in another way it's also very loose, with a great deal being dependent on choices the PCs make. As I recall, there are few if any encounters that can be just lifted out and dropped into another adventure. You could have the city-wide conflicts of MiBG happening as a backdrop when the PCs are there, I guess, but it would be hard to involve the PCs in any of them, and even describing them in any detail might be too intrusive. --That's how I remember it, anyway. You may think differently when you read it.
That said, it is definitely worth purchasing. It looks like an awesome adventure, for the right group, at least. And the sourcebook gives you a good overview of the city of Baldur's Gate and how it works. Plus, there's an NPC from MiBG who turns up in
The Rise of Tiamat.