buzzard said:It is an INERT gas. It CANNOT react with things.
You are correct, but (there's always a but)...
The chemistry of the upper atmosphere is not well understood. If you recall, certain chemicals were used as aerosol propellants and refrigeration fluids for many years, partly because they were largely non-reactive. Lo and behold, under the conditions found in the upper atmosphere, they do act a s a sort of catalyst for the destruction of ozone.
This does not say that large scale release of heluim would be a problem. A good scientist, though, doesn't say that an untested thing is safe. He says there's no known problem, because sometimes the universe throws you a curve ball. It's that never say never thing.
As for running out of fuseable hydrogen, sure, it can happen eventually. But then, the sun's gonna run out of it too, someday. We've got a lot of deuterium and tritium. Literal oceans of it.