Very few, if any, computer RPGS can dynamically react to the players actions in a realistic way.
Biggest example of this is the "monsters exist in isolation" syndrome. You enter a dungeon complex, fight a few monsters, get hurt, leave, rest for hours (or even days!), then re-enter the dungeon and take up right were you left off. The monsters in the next room are still there, waiting.
In a table top game, the entire situation can change if you leave the dungeon and come back. As a DM, I've often had almost all of the bad guys in the base leave if they become aware of the PC's and the PC's take to long to come in. (Or they all come and attack. Depends on what the bad guys know of the PC's reputation, and the bad guys motives.)
It used to be something I just accepted, but after so many years of playing D&D, it just kills my interest in the CRPG's. I bought the Morrowwind game, which had rave reviews, and lost interest after the first little dungeon complex my character entered.
Another thing: In table top games you can go outside the script in ways that you simply cannot do with a computer RPG.