This is a world building question. What’s the conflict?
So if you have a galaxy full of space empires. Say a dozen at least, each covering a big swathe of the galaxy. And you assume that:
1) space/habitable places isn’t an issue. Space is big and they’re not short of land.
2) a single resource like Dune’s spice or Discovery’s dilithium is a well-mined trope you want to avoid.
3) you want to steer clear of “species” othering: assume they’re all human and have similar motives.
How do you create constant conflict between these space empires? If indeed you can after ruling out the above?

(Dungeons & Dragons)
Rulebook featuring "high magic" options, including a host of new spells.