I DM online with FR. Fed up with it, though. I run 1e on Ert, my homebrew. Starting a HackMaster Game on Garweeze Wurld (no 4th edition CS available at present). If you want a published CS that's virtually system neutral, but still "official D&D" and damned good, pick up Kingdoms of Kalamar. If you do play 3e, there's also a KoK PHB. And a kick-ass atlas is coming out for it in December. Hoody-hoo! I plan on running Lejendary Adventures in Kalamar.