Because I like GMing quest-oriented campaigns, my characters rarely have a base and usually both being pursued and pursuing the object of their quest. It's a personal style thing. The other problem with having a home base for the characters is that they can easily become distracted just with gaining and maintaining power in their base; this tends to require ever-expanding lists of NPC names and stats as I struggle to keep track of anyone and everyone they might seek aid or information from. I don't mind a lot of NPC relationship bookkeeping but I find that urban-centred campaigns send this out of control and I end up tiring of it.
So I prefer a party motivated by a good combination of fear and fanaticism traversing the globe/plane.
So I prefer a party motivated by a good combination of fear and fanaticism traversing the globe/plane.