The Imperium deserves special mention because you could set a campaign at a great number of times. There is playable setting material for the Interstellar War period, Year 0 of the Imperium, the Golden Age, the Rebellion, the New Era, and the alternate history where the Rebellion didn't happen.
Just to put some dates
IY -2408 (2110 AD) is the start of the Interstellar Wars; they end with the "Rule of Man" (aka 2nd Imperium) in IY -2204 (2314 AD). GURPS Traveller Interstellar Wars uses this era.
IY 0 is 4518 AD. It's the declaration of the 3I. And the startpoint of the Year Zero setting; later works push to the IY 120 range. This is the default for T4 aka Marc Miller's Traveller.
IY 950 is the start point for the T20 Traveller's Handbook (d20 Travelller) Ruleset's setting.
IY 1100-1115 is the timeframe of the OTU as described in Classic Traveller. It's also used for Mongoose's Traveller (MgT). Mongoose is making a bunch of changes, so it may be better to think of them as separate settings.
IY 1116 to 1120 is the Rebellion; this is the start for MegaTraveller (MT). MegaTraveller continues on into...
IY 1120-1135 Hard Times. Setting not well developed, only one book, but it's a dark time...
1135 to 1200 The virus...
1200-1250 The New Era. The Reformation Coalition breaks out, and the Domain of Deneb gives up on reuniting the 3I in the near term... This is the default timeframe for the T:TNE edition.
1250-1350 the 1248 subsetting, for TTNE and T20.
IY 1900 - the official setting for T5 is in development. It's ... different.
I'm not sure how Traveller's Third Imperium setting rates in this. On the one hand, there's an absolutely massive amount of material from the various companies (and their own Open material) that have made products over the years. On the other hand - there's 11000 worlds in the Imperium, many haven't more than a short code describing them, one's outside often have less, so the detailed areas are rare. True also of course for other settings, but more obvious on the scale of a small patch of the Milky Way.
Traveller has a huge breadth... but it also lacks a lot of detail. 99% of the setting is represented only to the level of a mainworld name, and 40 characters of encoded data.