Indeed.(as long as it's done creatively/well)
Whoops. Inconsistent statements.The 3.5e campaign I run features an NPC named Glutinous Maximus, a gelatinous cube monk --well, he's really a magical hybrid of a gelatinous cube and a partially-digested human monk-- and former pit-fighter turned political candidate, whose eventual fate was to be killed by the party, resurrected by chaos magic in the Land of the Dead, and then imprisoned --much to his delight-- in the court of a demon lord, where he was made to pioneer new forms of pornography with the help of the demon's 994 succubi daughters.
And then there's our new 4e campaign, where I play a jolly Dragonborn paladin (and slam-poet) who marks his foes with his own semi-divine semen.
I find Paizo's Golarion deity Cayden Cailean to be too silly for D&D for me. He's a former alcoholic adventurer who became a god as a result of a drunken bet. Stranger things exist in real world mythology, sure, but the tongue-in-cheek silliness of this god singlehandedly ruins Golarion for me. I can't be sure of whatever other silly gamer jokes might also be inserted into the setting.
Nonsense. It takes many more words to explain exactly how clever and funny I am...(Of course, this does explain a lot...)

(Dungeons & Dragons)
Rulebook featuring "high magic" options, including a host of new spells.