I really like all of the giant lairs from Storm King's Thunder, but Grudd Haug stands out to me. I've run it as a DM and played it as a player. Lots of fun both times. Oooh, and Ironslag, the fire giant lair. It's got a rotating bucket system that will take you all around the map if you jump inside it. Brilliant design.
In a different thread a few days back (also started by Reynard IIRC) someone reminded me what a great little map Cragmaw Hideout is from Lost Mine of Phandelver.
Maps of towers typically annoy me but Feathergale Spire from Princes of the Apocalypse is the exception. I turned that into a heist scenario and had a ball with it.