I play in an in-person homebrew and a message-board homebrew. I DM a homebrew 2e email game and a d20 Wheel of Time message board game. But the 2e game should finally wrap up this year, and if I start antother D&D game, it'll probably be in the Realms. I'm not obsessive about the setting one way or another, but it's got widely available, really high-quality material, and as long as my players understand that if a character/event/whatever isn't mentioned in product I own (meaning a 3e gaming product, not a novel or a 2e product) then it doesn't exist/didn't happen in my game, I think it'll work fairly well.