Pirates can't be done, they never finished that cartoon series! 

That would be great.Considering how so few of the actual games have been released over here, the chances of an official RPG are none, but I'd love to see an RPG that was basically Super Robot Taisen/Wars with the serial numbers filed off.
I'd also like to see the following RPGs:
Pirates of Darkwater
Avatar: the Last Airbender
Half-Life
I always loved that show and wondered why it never got published into a campaign setting, especially during the time when TSR was cranking out settings left and right.
Riddick would be a pretty fast paced game if done right. Modules/adventures would focus on escaping planetary prisons and fighting invading arms. It would have to include large scale combat rules I think.
Hey, you forgot the Vincent Price version! One of these days I need to see the Will Smith version.I Am Legend... it would be the ultimate in one player, one DM games! It would work because it would carve out a niche for itself.
(My admiration is of the book version or director's cut of the recent film, not the Heston film nor the Smith movie theater release version.