Due to obnoxious circumstances of location, culture, and the need to focus on education, I pretty much missed out on 3E, outside of a single adventure I ran online (though I bought my share of books, eh heh...). 4E comes out now that I'm better set up to play online, and just before I'm planning to move to an area rich in appropriate culture (hopefully Seattle itself), so it's perfect for me to jump back into gaming with.
The design style also works extremely well with my fantasy preferences (though 3.5E touched on a major part of them with Incarnium), where warriors can take down wizards one-on-one without a single magic item, and spell casting is much more personal than whatever spellbooks you've dug up.
4E just clicks with me on so many levels. I have a few things I may houserule, but I love the overall design philosophy. May help that I have no loyalty to the old school styles of wading into dungeons with hobbits.