My old 2e campaign ran in the Cairn Hills/ Abbor-Alz region (at first) before expanding to encompass the Free City, a trip to the Yatils, and a short trek to Tenh.
Most recently I ran a campaign in the Vesve/ Highfolk/ Yatils region, which included some themes of the Wolf Nomads being displaced and a war against a powerful dragon.
Presently my new campaign is in Womtham, a major city in Nyrond, near the Flinty Hills. Orc incursions, a shanty town, taxation, and corruption in some of the Churches will come to the fore, I hope.