If it counts, Dungeon Magazine. I'm getting a lot of mileage out of the Age of Worms. Besides that, Lords of Madness is the book I most enjoy using. My players cringe slightly whenever I pick it up.
Technically, even though it's a 2e AD&D supplement published by WotC, I really like The Apocalypse Stone - not so much for the actual adventure, though, as for the ideas on cosmology and terraforming settings that it provides.
From only WotC stuff, Unearthed Arcana or the Monster Manuals as a group.
As far as from everything sitting on my shelf, it's an even chance of being Central Casting's Heroes of Legend, my assortment of monster books, or the Campaign Toolbox.
Out of my entire collection, it's the hot new copy of Elements of Magic: Revised.
/shameless plug.