Add me to the "something new" category. For crying out loud, enough re-boots (and this goes beyond RPGs into cinema). How about some fresh ideas. Re-boots can sometimes be great (e.g. Casino Royale) but usually mediocre at best (Star Trek).
I'd like to see them go all-out on a new setting, and then turn the story arcs into classic setting revisits with either a regional gazetteer to go along with the adventure or at least a section in the adventure detailing the region. Tyranny of Dragons was a missed opportunity, in my opinion - it should have included a gazetteer of the Sword Coast to help facilitate continued play in the Realms without buying OOP product.
So then you can have two "streams" of setting/adventure product:
A) A New Setting with ongoing supplementation and adventures.
B) Classic Setting Story Arcs - in 1-2 books, including a regional gazetteer.
Make it so, Mearls.