..., Big Pharma, ... something that the PCs know must be opposed ...
Yea like, omg they say they have found a shot vs. the zombie apocalypse, but in reality they only want to inject you an intellect devourer ....
..., Big Pharma, ... something that the PCs know must be opposed ...
I like the idea of an evil, very powerful, but non-violent villain. The PCs can't take him down by dumb brute force, but he's also not going to just hunt them down and murder them. Nice dynamic, it encourages strategic thought.

(Dungeons & Dragons)
Rulebook featuring "high magic" options, including a host of new spells.