The single most applicable response seemed to be "I mix sf and fantasy". I like a little bit of a mix of sf in fantasy, but oddly enough I dislike adding fantasy to sf if that makes any sense. Elves and dwarves in outer space flying magical galleons is fine, but Elves aboard the USS Enterprise or Millenium Falcon makes me wanna gag.
Mixing RULES is really a different question from mixing genres because when we do it, it's for very different reasons than mixing genres. Still, almost ALL of my experience at mixing various rules systems together comes from SciFi games. The first was a mixture of Space Opera and classic Traveller. The next was a mind-blowing conglomeration of bits and pieces from all the OTHER editions of Traveller except the original (twilight 2000, 2300, etc.). Even the DM who inflicted it on us

referred to it as "Hybrids & Headaches". I think that one sorta soured me on mixing rules - but genres I have much less of a problem with.
SF monsters like Predators and Aliens, space flight, ray guns, contemporary guns, robots, steam trains, submarines, travelling to contemporary America, contemporary Americans travelling to D&D settings... all that kind of stuff has at least a potential for showing up in my D&D game one way or another. I'm currently leaning toward a new campaign where clockwork constructs will be a common encounter, and perhaps even be a PC race.