The Lands of the Diamond Throne setting for Monte Cook's Arcana Evolved is, for me, the quintessential non-human-dominated setting. The Diamond Throne itself is ruled by a benevolent race of civilized giants who liberated the continent from the thousand-year rule of the dramojh, hideous abominations that combined the worst aspects of demon, dragon, and spider. The only significant challenge to the giants' hegemony comes from the dragons, who claim the entire continent as their homeland, and likewise rule over the humans within their territory. Although one small, isolationist human empire and a smattering of independent city-states exist to the far south of the setting proper, no human nation in the history of Serran has lasted for more than 200 years before being conquered by non-humanoids, so it seems only a matter of time before they too, collapse. Although humans breed fast and are thus the most common of the half-dozen races of the setting, they hold almost no political power in the major nations, while three of the PC races (Giants, Verrik and Faen) rule their own nations in addition to intermingling freely with human cultures, and another maintains semi-independent tribal rule (the Litorians).
Robert "Giants Rule: Because Humans Have Already Proven Their Incompetence" Ranting