I am finding it difficult to figure out how difficult this fight will be. The encounter is x1 Medusa Template and x4 level 5 Life Domain Clerics. The Clerics are blind, and are essentially the Servants of the Medusa, and during combat they almost universally use their magic to benefit her, not harm others, especially since they can't see. Now they do have Spirit Guardians, and will likely use it if they feel they need to. As for the Medusa, she will stay back with the Clerics and use her bow for as long as she can while using her petrifying gaze when someone tries to close the gap with her. The encounter room is essentially a 90x40 ruined throne room, with the primary entrance at the other side of the room, and the Medusa at the throne with her cleric servants. Essentially, I do not know how much more difficult the Medusa should be assumed to be since she will be getting a great deal of healing and buffs. Does anyone have an idea as to how to calculate this?
First off, welcome to EnWorld!
As for the encounter, the NPC clerics are basically the Priest entry at the back of the MM, so those are CR 2. However, if you make them blind, that severely restricts what they can do. As has been mentioned, most of their spells will be useless in such a situation. I'd suggest giving them 10' blindsight (some sort of divine sight?), as that will at least allow them to target each other and the medusa.
The medusa is CR 6, but a lot of that is the gaze attack. Since that only goes out to 30', a smart party will just stay at range and trade shots with the medusa. It will only get two longbow shots for an average of 6 points of damage per shot vs. multiple attacks from the party. In other words, with this setup, the medusa is toast with minimal risk to the party.
Now the blind priests helping the medusa is a cool idea. In practice, however, they'll be limited to casting
cure wounds on the medusa, which will just drag out the fight. Bottom line, a 6th level party with area effect spells and decent ranged attacks will have little trouble with this encounter. It will use up some resources, so call it 2,500 - 3,000 XP total.
What you need are additional environmental effects. Here are some possibilities:
Make sure the characters have to enter the room to attack the medusa/priests. Have the floor in the room covered with ornate symbols and diagrams. Anyone standing on the diagrams must verbally chant something from the priests' religion or be hit with 1d8 necrotic damage. Meanwhile, hidden on the floor are a handful (not too many) of
glyphs of warding with
hold person, blindness, or
guiding bolt). These should be placed such that a quick rush of the medusa is a bit risky, but possible.
With something like this, the characters can battle at range, but it becomes a race to take down the medusa before the necrotic damage takes them down. If they rush the medusa, as soon as one character triggers a
glyph, they'll be worried about more (which is why you don't need too many - the idea is to worry the party, not wipe them out). And once close to the medusa, the gaze comes into play, as does
spiritual guardians. All of this should force a quick, tense fight, rather than a somewhat tedious ranged, attritional fight.
With additional environmental effects, I'd bump the encounter difficulty into the 4,000 - 6,000 XP range, depending on just how tough the effects.