As was mentioned in my thread on 5th Edition, I would place a series in Eberron and feature a strong female lead who was a heavy infantry-type fighter. She would be a human Brelander and veteran of the war.
The party would almost certainly include a half-orc druid to serve as spiritual guidance and healer, and there would have to be a changeling who is either a member of the party or their most important ally. A changeling could in fact be an amazing character that allowed a bunch of guest stars to all take on a different aspect of the same character. One should probably have a dragonmark, though in some ways it might be more interesting if it was an aberrant mark and kept under wraps. Hell, it might be really interesting to have a dragonmarked heir AND an aberrant dragonmark character.
Each season should have an overarching plot, with the initial season perhaps having four or five " chapters " while if it was succesful later seasons might feature a single season long " chapter " (where a chapter encompasses an adventure or the equivalent). Adventures might have different tones, with some focusing more on investigation, and others on adventure. I think it would be interesting to having a narrator that has taken lessons from classic noir, Desperate Housewives and Gossip Girl.
The Emerald Claw and the Aurum (especially given this day and age) would be major villainous organizations, with dragonmarked houses and various nations sometimes playing the bad guys. A confrontation with the Lord of Blades would probably be a major mid-series event, with the whole series building towards a final showdown with one of the Lords of Dust.
