Mercurius
Legend
All of the old TSR sci-fi games—Gamma World, Star Frontiers, Metamorphosis Alpha—seem dated; in a fun way, but not a way that I would think WotC would want to run with.
If they do go sci-fi, I would expect either an updated version of Alternity, some kind of near-future dystopia (apropos to the times), or some kind of science fantasy ala Numenera/Spelljammer.
If they do go sci-fi, I would expect either an updated version of Alternity, some kind of near-future dystopia (apropos to the times), or some kind of science fantasy ala Numenera/Spelljammer.