Today the official geography of the D&D worlds could be totally retconnected. I mean today with the right software the computers can create the continents with the tectonic plates, seismic zones, volcanoes and local climate.
Other option would be the quasi-canon settings, for example Exandria(Critical Role) but also other potential franchises, for example "We will be monsters", a reimagination (and very radical) of the Universal Monsters like a spiritual succesor of "Mask of the Red Death". Blackmoor and Gary Gygax's IPs could follow the same path, working like a limited Ed.
If WotC wants to create a special style of D&D for the Asian markets, Kara-Tur could suffer some retcons (you can blame the Sundering Event) but the celestial empire in Oerth could be designed for them (my fear is the Asian fandom has got their own predjudices against their neighbours, they aren't used to be so cosmopolitans like most of European nations. Have you seen the fantasy realms and races from manga, manhua and manhwa or Asian fantasy videogames?).
My theory is Hasbro wants cosmology by D&D multiverse to be enough flexible and open to can add later crossovers or no-fantasy franchises, for example Gamma World (Hasbro would capable of a Fortnite/Gamma World crossover at least to sell action figures and other merchandicing products. It know, it is a crazy idea, so crazy than it could become real).
I wonder about fantasy adult animation with a "retro/vintage" art style (like the animated movie of Dragonlance).
And we can't know the future deals between Hasbro and other companies. For example if there is a future merger between ViacomCBS and Comcast WotC could be offered deals about Universal franchises (or even Star Treck RPG could leave Mophidius to become d20), or Disney could offer a rerun of D&D cartoon, or WarnerDiscovery offer a reprint of the D&D comics by DC in the 80's (and Entertaiment-One has got deals with Discovery Family). Maybe Hasbro would rather to await because 2022 will be a year of radical changes in the media and entertaiment industries. Licencing D&D worlds with different companies? Too complicated, and worse if you want crossovers.