Gradine
The Elephant in the Room (she/her)
I'd considered some of the friends from other Spider-verses (because Green Gobbo and Doc Ock were still incredible as always) but I decided not to reward the MCU for cribbing its' older siblings' notes.I'd claim Jeff Goldblum's Grand Master in the Great category, even if he's a "side villain". And if you're including Spider-Man movies, I think Green Goblin and Doctor Octopus could use at least an honorable mention.
But the main point is well taken, the MCU could use a better standard of villainy. Right now, I'm hoping they won't eff up Doctor Doom or, if they have him as more of a villain, Magneto.