Remathilis
Legend
You're never going to get a Monster Manual that does that. You're only hope is to create every monster from scratch or pull from nonstandard sources. The classic monsters of D&D are well explored and overexposed due to 50 years of Monster Manuals, modules, Dragon mag articles, and tie-in media. You aren't going to get the mystery back.I am not beholden to the name or concept of orcs, orc is mostly a common CR 1/2 stat block. If orcs cannot be alien enough any more, then replace them with something that can. The goal is to reintroduce something alien and 'scary' into the game, orc or otherwise, instead of everything just being friendly humanoid races in the valley of sunshine and rainbows.
I actually think Paizo did something that could work: they conceded some monsters to becoming ancestries (orcs and goblins) but used their Revised Bestiary to remove and change as many D&D stalwarts as possible. You can't rely on ancestral knowledge of D&D in Pathfinder anymore. There could be a very interesting product for someone to make an alternative MM that takes the classics in wild new directions. But WotC won't be that someone. They have to play the hits or people will riot.