Greyhawk certainly took a lot of inspiration from Tolkien and I am fine with that. It does make it hard to justify some PC choices. The average village is fearful and xenophobic. Halflings, elves, and dwarves may be welcome or tolerated but a gigantic goliath or a woman with demon blood? I think it works as long as players and DMs see it as a role play opportunity and don't complain that it's so unfair that everyone hates my giant insectoid. In the real world, people in not very remote settlements hate people of different ethnicities, so it's not even unrealistic.
I think the problem with human-centric campaigns might come when no players want to play humans. So a group like Vox Machina (with one human) look like a bunch of weird outsiders to the average person.
I think the problem with human-centric campaigns might come when no players want to play humans. So a group like Vox Machina (with one human) look like a bunch of weird outsiders to the average person.