Anakin, Padme, Obi-Wan and Qui-Gon sure, but the prequels had CGI characters like Yoda and Jar Jar (for better or worse). However, there has been a major backlash against fully CGI characters due to them looking "fake" or "videogamey" so practical effects went back into vogue, and unfortunately prosthetics and masks don't emote very well. And once you get into TV (even streaming) budgets, you kinda end up back into Star Trek level "human with fancy Halloween makeup" levels of alien design.
Compare any of the live action Star Wars shows to Clone Wars/Rebels style animated shows and you'll see how many more unique alien designs get used.