I have said several times in the past 5e is not ready for no-fantasy genres. Here WotC would need to publish a 20 Modern 2.0. And the power balance would be a hell for the game designers.
And a good setting needs a great variety of enemy factions. Star Wars is very popular but there is only two factions, while in Star Trek there are different groups of enemy factions.
I confess some time I tried to imagine some mash-up of sci-fi franchises within Spelljammer setting.
Conan the barbarian will be public domain in 2028.
I don't advice IPs where characters have a different power scale style jumping on the roofs or breaking walls with their fists. I could give examples of isekai where the main character is broken or OP even in the first episode for D&D standars
I don't like the "only-human" franchises, or where there is only an enemy faction, or only the heroic group solve all the troubles, without space for others, those franchises with a good plot but a bad worldbuilding.
* I would bet for Warcraft. Here Blizzard would earn brand power for the IP.
* My favorite videogame franchise is "Fortnite: Save the World" (the original tower defense, not the superfamous Battle Royal).