trappedslider
Legend
It depends on the mods you have installed and your own hardware. The actual hard limit of mods is 255 (ESM/ESP files) mods and it's possible to go above that number due to some mods not being flagged as ESM but instead ESL. Like i said I currently have 310 total mods and my game is stable and running fine other than built in issues that haven't been patched by a mod or by actual patches.Does CPU/GPU load increase after a certain number of Skyrim mods? I think I'm close to 50, which runs fine, but some of my NPC encounters are glitched.
Most of my mods are various animations followed by character replacers, new items, a few overhauls.
I've had like 80 Skyrim mods before and been just fine, but I've also installed just a few mods and had problems because they were incompatible or heavily used scripts or the like.

As of now my fallout 4 game has 242 total mods.