Add Man O War (GW's best game evah) to the casulty list.
And the specialist games Dragonbait lists are pretty much on life support (mainly because GW themselves knifed them in the gut,not due to the market)-not getting anything like proper support,books or models.
This is why I dont play any...
Having played and ran many games with multiple different versions, it mainly depends on the game itself.
Shadowrun:for the most part every new edition has been a great improvement on the last (though I have 4th and have thumbed through it,never played it or read it cover to cover yet so no...
While initialy CE (Pre-Pitch Black) in Pitch Black he actually developed a conscience and understanding of self sacrifice (witness his plaintive "it wasnt supposed to be her" (or something to that affect) when Carolyn died.
And then the fact that he ran away from civilization to PROTECT Kira...
Depends on what you want to run.
Personal/Perenial Faves I would recomend are:
Exalted-though more for the setting than the system
Shadowrun
Feng Shui- quick and dirty lite system focused on action movie RP
Blood of Heroes (aka MEGS, aka DC heroes)- My favorite superhero system hands down...
Far Future Enterprises http://www.farfuture.net/ Has most of the old GDW trademarks/rights, though they dont seem to mind multiple versions (Currently there is GURPS Traveller, T20, The Classic Traveller reprints, and the rumored T5)
Of course at its core Twilight 2000 is generic enough that...