Gravenhollow
Red Sky Fever
In our campaign, Yuraddal, a night hag, cursed/infected the three librarians with
Red Sky Fever to assure they were incapacitated. The heroes had to venture into their bizarre dreamscapes to save the giants.
Red Sky Fever originated from an ancient conflict that brought a company of stone giants warriors to
Pazunia, the first layer of the Abyss. The campaign went bitterly wrong when some of the giants started succumbing to madness and became abyssal
dreamwalkers. At great price to the giants, an
altraloth cured their jarl of the madness, but actually extracted the fever as a culturable essence to trade to night hags. Unlike a common disease, Yuraddal delivered the curse of Red Sky Fever by placing a specially prepared medicine bundle (vrock feather, prickle vine, etc.) under each giant's bed.

The initial symptoms were high fever, delirium, red eyes, and veins became dark and prominent. The next stage (if the giant hadn't died yet) was dream walking. Their delirium leeched out affecting the reality around them to such a degree that it created a
demiplane. Shaped by the giant's fevered nightmare, it was connected to Pazunia as a "closet". The final stage was death and transformation into a unique, huge demon, unless the giant stabilized.
If a DM employs this twist, the formula for a curative elixir can be researched there in Gravenhollow and brewed, perhaps calling for components that include one or more odd things the player characters just happened to collect in their adventures. This can be done by the PCs applying their skills in
Investigation and
Arcana, or by engaging an NPC (e.g.
Vizeran DeVir). In our game, they learned of an additional use of the
Stonespeaker Crystal. Placed on the sarcophagus of a past librarian, named Trirza, her "echo" appeared and orchestrated the brewing of the elixirs.
Each librarian was somewhere in his/her nightmare standing entranced by the created world. The physical laws and environment were very strange. The trick was for the party to penetrate the dangers and obstacles to reach the giant. Thereafter, it was a matter of convincing the giant to drink the elixir, which could be mixed into something else (ale, milk, wine, etc).
When the giant consumed the elixir, the demiplane quickly dissolved and returned the giant to his quarters. The heroes had to act fast to avoid being trapped in the Abyss. The librarian still remained in a fever, but was assured of recovery in the coming days (unless Yuraddal interceded).