I know that they're going to do more Organized Play friendly stuff, but since this is a wishlist I'm going to put down the things I'd like to see that I doubt that they'll be doing. I kind of like having big epic adventure paths, but they aren't going to go on the wish list because I know we're getting those
I want more books like "Threats to the Nentir Vale" - organizations and creatures with adventure hooks built in that I can plop into a game without having a full fleshed out adventure, but that can connect to each other in interesting ways. This book has been incredibly handy for those times when I'm trying to figure out what going to happen next when my players have just finished foiling a nefarious plot of some big bad guy and I'm looking for ideas to help build up to the next nefarious plot that needs foiling. I would even take this as a digital only release. I would possibly even subscribe to a bi-monthly or quarterly magazine that was nothing but this because it's not just useful, it's kind of a fun book to read.
Likewise the Neverwinter Campaign Setting has been a great resource for similar reasons and I want to see more like that. I don't even run a Forgotten Realms game but I've been able to strip ideas and factions from it and repurpose them more easily than in a lot of previous products. I don't know what about the design of the NWCS makes it friendly for doing stuff like that, but it has been for me. So whatever they did there they should do it again. (If I want to make this wish list ridiculous I would demand a Neverwinter-style Campaign Setting treatment for the city of Specularum and the surrounding area from the Mystara setting, but since I have a better chance of winning the lottery than Mystara does of getting a new product line, I won't.)
As almost the a complement to the first request, I also want to see more location-based adventures that don't necessarily have much in the way of plot to them but are just interesting locations that are connected together via thematic or backstory strands rather than as plot points that characters are supposed to hit. I got a lot of mileage out of Thunderspire Labyrinth because it was that kind of adventure. I threw away the plot and just used the locations and some of the organizations in it, fit them into the plot we'd already had underway, and it worked out great. My ideal for DMing is to have a collection of locations that I can rifle through and retheme to work with the plots of my villains or the goals of my player's PCs. Thunderspire ended up working out great for that, so I'd like to see more of that. And again - I'd buy digital only releases of that instead of full-on books if that's what the market supports.
That's about it. Except that at some point I want to see Star Frontiers get the D&D treatment the way Gamma World has gotten the D&D treatment for every edition of the game since 2nd

Star Frontiers missed out since Wizards had the Star Wars license for most of 3rd and 4th edition, so it's high time that they tried dusting that trademark off and giving it a new go.