I have played through SKT and run it once. I love it. One of my favorites.
For my run-through, I made the PCs all be Lords' Alliance agents based out of Waterdeep. I ran "Trouble in Red Larch" from
Princes of the Apocalypse and then followed that with a slightly beefed up version of
Scourge of the Sword Coast to set the scene and give me time to set up some foreshadowing. (For instance, during
Scourge, the PCs found some magic beans. I arranged it so when one of the beans was planted, it did the giant bean stalk thing. That led to the cloud giant's Mickey Mouse tower from the opening SKT scenario. He was able to give them some foreshadowing about the SKT events as he flew them to the dwarf temple-fortress.)
Some of my players are big Skyrim fans, so they loved the open world "exploring the Savage Frontier" aspect of that part of the adventure. I ran the Goldenfields encounter, and they went and defeated the hill giants at Grudd Haug. They also passed through Triboar on their way elsewhere, so I ran the fire giant encounter there. One of the PCs was a ranger, and they knew about the Mielikki shrine in the nearby woods. She went and spent the night there, and I gave her a prophetic dream showing the storm giant queen dead on a beach and the other giant lords scheming.)
I'd be happy to share my notes.
Here are our session recaps:
SWORD COAST ADVENTURES