A new edition is a good opportunity to start something new - whether an entirely new world, and new campaign, a different kind of campaign, etc. So as the thread title says, the question is: Are you doing something different with 5E? Or is it business as usual? Or somewhere in-between? Tell us about it.
I'll start. I ran an on-again, off-again campaign for 4E over the last few years, which has dwindled over the last couple years as I returned to school for an MA. But the good news (on multiple levels) is that I'm finishing up my degree and hope to start a new campaign come January, so I'm in the early stages of planning.
I'm using the same setting as the last campaign, but with some moderate changes. I'm focusing more on a smaller region - the Fringe Lands, which is kind of a hybrid of something like the Dale Lands of the Forgotten Realms (but wilder), a touch of Hyboria, a dash of Middle-earth, sprinklings of Earthdawn, and tonal qualities of the American frontier. Oh yeah, and plenty of my own seasonings thrown in. I'm still playing with campaign ideas, but as I said elsewhere I'm thinking of integrating elements of the Walking Dead. I might have the PCs start off on a relatively run-of-the-mill adventure, as young "off-the-farm" types looking to make names for themselves, and then returning home after their first learn-the-new-rules adventure (a couple levels later) to find their home town on lock-down due to mobs of zombies. I'm still playing with how I want to do it, but the idea would be to build to a point where the land is over-run by different kinds of undead, and it is up to the PCs to figure out why, and stop it. So it is Walking Dead, but on a smaller scale and solvable. I'm thinking it would be more of a mini-campaign--levels 3-8ish or so--before moving on to something else.
The main thing, though, is that I want to integrate elements of both sandbox and story arc. The game would play like a sandbox in that the PCs would have to figure out what was happening and decide where to go, but there'd be an in-depth metaplot that was playing out (undead incursion) which they have to deal with.
What about you?