One thing keeps coming to my mind, here. Dragons, apparently, sleep around. I mean, if Bruce Cordell were to have his way, they'll mate with anything with a pulse (take a look at Bastion of Broken Souls). It would be rather interesting to see a write-up of how they approach that sort of thing. 3E has provided a large body of half-dragons and other templated creatures that could use a little discussion, if only from the 'how do the genetics of this work' to 'how do dragons approach relations with other creatures, why do they do it so often, and do they have other goals in mind?'
By the same token, though I wouldn't want a discussion about it, Half-Orcs are right there, in the core. The unspoken assumption is that, generally, they are the products of a non-consenual coupling, isn't it? Maybe that should be represented differently, and possibly presented in a different light.
I'm not really sure what I think of the book, per se, but I think there are plenty of topics in that light that could be addressed, if handly properly.
I think the real issue here is the press release was put out to blatantly manipulate the online fan-base. It has suceeded in generating talk about the product, certainly, but I think it may have also soured some folks on the actual product sight unseen. Whether it will share space with our XXXenophile collections and Book of Vile Darkness or not will depend on the content. Hearing that Gwen Kestrel is involved gives it a few points back from what it's lost out of the gate. I will wait and see.