George (Savage D&D game): Mostly Lenny (Of Mice & Men) with a bit of Puck and the Human Torch.
Seth (Lochmar Clan D&D game): Captain America with a healthy dose of Thanatos (Incarnations of Immortality)
Terrius (Exalted): Jen Yu (Crouching Tiger, Hidden Dragon) with a healthy dose of Black Mage and a bit of Xander.
Jezmund: Galahad meets Bugs Bunny.
Zako: (from Lodoss) 3 parts Parn, 2 parts Wood, 1 part Orson.
Antoine Le Scouarnec: Oscar de la Hoya & Buddha
Uriel Sevtéline: Varsuvius (OotS) + Tim the enchanter (Holy Grail)
"Prophet" is equal parts Bacon from Lock, Stock, and Two Smoking Barrels and Rusty from the remake of Ocean's 11, with a slice of Ulysses Everett McGill from Oh, Brother! Where Art Thou? (because, let's face it, the dice don't always go my way like they seem to do for Rusty), and a dash of Kaiser Soze thrown in to add something a little more menacing to his devious, but (mostly) good nature.
I don't play much, but a favorite NPC of mine would be 1 part Faye from Cowboy Bebop, 1 part the collected albums of U2, 1 part G'Kar from Babylon 5 (his entire character arc), and 7 parts Jade from Jackie Chan Adventures, wrapped up in a cute dark Elven sorceress package.
My current character is Eldon Greenbottle a halfling cleric of Larue. I would say that he is part Lucky the Leprechaun ("There always after me lucky charms!") and part Dr. Van Helsing from Dracula.