Since the system has been confirmed, the D&D vs Daggerheart debate is redundant (and it was already worn out) so, in a bid to move beyond it, I thought I'd engage in a different form speculation on campaign 4, based on the information revealed in the announcement.
The cast has been expanded from the core 8, to include Robbie Daymond, Aabria Iyengar, Alex Ward, Luis Carazo and Whitney Moore. BLeeM mentioned splitting up the cast into three (3) groups based on playstyle: Soldiers - a focus on combat; Seekers - a focus on lore and exploration; and Schemers - a focus on intrigue. In the fireside chat, BLeeM said he expects the groups to intermingle at some point, but also mentioned they've got the first 4 episodes recorded, so that means the starting groups are already locked in. Based on previous play, I think a potential grouping might be the following:
Soldiers (combat)
Liam: Liam seems to have a bit more balanced playstyle than others, however, his class choices have trended towards the combat focussed subclass - assassin rogue, evocation wizard, battle-master fighter.
Luis: In EXU, he played a paladin that tended toward action, and in Private Nightmares (a V:TM actual play GMed by Alex Ward) he played a Brujah-sired thinblood, so Luis seems to gravitate towards being combat-orientated. It should be noted that he's a notetaker (though not quite to the same extent as Marisha), which demonstrates an interest in the world, so Seeker is a possibility.
Sam: This might not be the obvious place for Sam, but his most iconic moments have been during combat: the Lv9 Counterspell during the Vecna fight in C1 and the self-detonation in C3. While he clearly enjoys a bait-and-switch, and likes his characters to have a secret that ultimately comes out, suggesting Schemers, Sam hasn't really demonstrated much interest in uncovering the machinations of others, nor the setting.
Travis: Action in general, and combat in particular, is where Travis gets the most enjoyment. He seems to enjoy plot twists and reveals, but he doesn't really engage much in investigation of setting or NPCs at the player level (as opposed to utilising those skills as a character). When the words "roll for initiative" are uttered, Travis perks up.
Seekers (lore/exploration)
Ashley: Ashley is a fairly passive player, so it's not immediately obvious what group she'd be in, but one thing that stands out with her is how she hangs on every word when Matt is engaging in exposition. She also tends to struggle with what to do in combat and hasn't demonstrated much interest in intrigue.
Marisha: More than anyone else at the table, Marisha takes notes. She's the one who remembers that thing Matt mentioned once 20 sessions ago. She's the one constantly asking questions and demonstrating curiosity about the world. This curiosity could push Marisha towards Schemers, but I think Seekers edges out.
Matt: This one should be obvious, but Matt's a worldbuilder. Exandria has some elements clearly inspired by Nentir Vale and Eberron, as well as various Soulslike games, highlighting Matt's interest in other settings. Coupled with the various chats where he nerds out about setting details, man's clearly a lore nerd.
Robbie: Not a lot to go with Robbie, but he chose a bard for C3 which isn't typically the class one picks if their main interest is combat. Granted, he chose College of Swords, but still gravitated towards words over action, and support in combat. Schemers is a possibility, but he seemed to have most enjoyment when elaborating on backstory elements like the family connection of Coriolis.
Schemers (intrigue)
Aabria: Given she played a abjuration wizard in EXU and a life cleric in C3, one might think Aabria would be in the combat group in a supportive capacity, but she's also played in two V:TM actual plays where her characters seemed interested in manipulating others either for fun or to get ahead. Both were shorter in length, so I could see her wanting to scratch that itch in a longer campaign.
Alex: Alex has a love of V:TM on par with Matt's love of D&D, and a core element of that is plots and schemes. This seems right up his alley.
Laura: This might seem an odd choice based on the characters actually played, but hear me out: for C1, Laura wanted to play a rogue, but was beaten by Liam, choosing ranger as the next best thing; for C2, she wanted to play a warlock, but was pipped by Travis, so went with a trickery cleric; then Sorcerer for C3, but she would consistently try a social approach first, so Laura seems to want to engage in guile.
Taliesin: Based on characters actually played, I'd say Taliesin is actually more combat-oriented, but given his love of Call of Cthulhu and Vampire: The Masquerade, I reckon he'll want to be in the intrigue group.
Whitney: Whitney is the wildcard since I haven't seen her in much - a show on Geek & Sundry which I can only describe as a post-apocalyptic Clarissa Explains It All, one of Ivan van Norman's games of Dread, and a cameo on a V:TM actual play. I have no idea which group she'd lean toward.