I just finished DM'ing my weekly game about 20 minutes ago. The nearest of the five players in my group lives about three hours away. I almost never play FtF anymore.
Which is to say, I am very interested in the DDI, and I hope to hell Wizards can pull it off.
Their track record, however, does not leave me with high hopes.
To Clueless: How long have you been using Klooge and how well does it work for you? We gave up on it after a few months because it tended to fall down, sometimes over and over and over again.