Saeviomagy
Adventurer
Yeah, but the historical/traditional answer is "blindside your players with something that kills their character without giving them a chance to prepare or fight back, they can always roll a new character".In D&D, the traditional/historical answer to this question is 'No'.
That said: fire resistance should protect you against the "your lungs get burnt and you cough up blood" half of smoke inhalation, leaving you with the "it's hard to see and breathe" bit. As long as you make it clear that characters are going to need air, I think that's fine: don't just silently tick off rounds and then say "Surprise! You suffocate!"
Clouds of sulphur on the other hand? You'd need to decide if they're poison or acid. Probably poison, since demons, devils and elementals are handily immune to it, and D&D seems to reserve "acid" for things which literally make your entire body dissolve rather than things which kill you by dissolving very tiny bits of you.