Dragonstar/Dnd Farscape
I haven't put hard numbers/rules to it yet, but I have been playing with the idea of a one-shot Farscape game. As a computer programmer, I subscribe to the KISS (Keep It Simple, Stupid) principle.
Humans, Sebaceans, Nebari and anything with no special abilities: Use Human for race.
Sebaceans' heat sensitivity would probably involve Fortitude saving throws to avoid losing temporary ability damage--miss two roles in a row and take permanent ability damage.
Use Half-orc stats for Luxans? Make qualta blades an exotic weapon that takes a standard action to convert between modes (bastard sword and blaster rifle).
Delvians have some interesting abilities: like blooming and causing major allergic reactions when they get hungry.
Hynerian: Use Halfling stats.
ok, classes then (you can argue levels and ability scores ad nauseum):
John Crighton Expert/Pilot/Fighter [Expert for being a scientist? or just ditch Expert for levels in Pilot? Definitely weighted toward Pilot]
Aeryn Sun: Pilot/Fighter [weighted toward fighter I think]
Ka D'argo: Fighter
P'au Zotoh Zhaan: Cleric [cut down the spell list? or just use Psion?]--editorial: it sucks that they killed off Zhaan!
Rygel XVI: Aristrocrat/Rogue [I'd also give Rygel a low Constitution and Strength since he's a pampered Dominar who's never done anything for himself. Maybe the Negotiator PrC in Dragonstar?]
Chiana: Rogue [High Charisma obviously--maybe even give her Charm Person 1-3x per day for fun

]
Jool, Stark, Pilot, Crais: We have enough PCs for a good game above. These guys could be NPCs or extra players for a big game