If you're open to True20 (it's my preferred system for Future and Modern games, which is why I design for it), and you're willing to wait until next month, Reign of Discordia will be out. What exactly is Reign of Discordia? It is a space opera setting for the True20 system. The easiest way to explain it is to think of the fall of Rome, in space, with aliens. It is a star spanning setting where the core rules provides you with over 50 core worlds, seven unique alien species (assuming you count humans), around twenty major organizations (all of which are loaded with adventure hooks) and tons of campaign models you could employ.
My philosophy when writing this was to provide a setting that was more about adventure than hard science fiction, although an attempt is made to explain complex technology like faster than light travel rather than simply hand waving it away. It also serves as kind of an everything and the kitchen sink type of setting. If you like Firefly and want to run a gritty game where your job is to get a job and get paid, you're covered. If you want to run something a little more military, you're covered. If you want to run something where you're battling a seemingly unstoppable force - yep, it has that too. There's even areas and reasons to do some classic dungeon delving with a scifi twist.
Finally, with regards to the art, I'm still waiting for it to come in, to be honest, but the idea behind it was to go retro-future. I'm really interested in using the type of scifi images that were popular back in the late 1970s rather than the CGI look of today. I come from a certain generation that was raised with science fiction that had a certain look, and I hope that this will come through in the final product.
One final note is that if you like the fluff but prefer D20 Modern and have D20 Future, there is absolutely no reason why the setting wouldn't convert straight over. Much of the chunky rules material in the core book was a conversion of the Future OGL to True20, altering things somewhat to match the setting.
Hope you check it out. The link to the press release is in my sig.