3.5 Private Sanctuary (stays on message... very focused)
Dragonlance Canticle (Mainly interested in the topic... VERY specific to a certain setting but all too few episodes of late... know what I mean Dragonhelm?)
Fear the Boot (once my "go to" podcast but now an exercise in what NOT to do. They either take themselves too seriously or let Chad just run wild... and not in a good way. I listen more out of habit now and may be dropping it soon.)
Happy Jacks RPG (a 4e podcast but their banter is gold... banter at it's best but it IS very irreverent)
Know Direction (a Paizo Pathfinder centric podcast by one of the hosts of 3.5 Private Sanctuary... again, a topic specific podcast)
RPG Circus (not the best but getting better... the hosts are a bit TOO laid back and need pepping up)
Save or Die Radio (hands down current favorite... all games discussed... and the hosts have a very friendly feel to them)
Smiling Jacks Bar and Grill (another topic specific podcast... in this case, a Savage Worlds centric podcast... only had 1 episode and it may have podfaded all ready... too bad... sigh....)
Mainly I look for the topic/content first... personalities second... punctuality third (if you don't release a podcast, I can't listen)