Guys, let's clear the air on a few points here.
Some folks seem very engaged on the Constitutional portion of a 'protected class'. There are already federal laws on the books that protect gender identity, and the Indiana law has no force against them. Example: the Equal Employment Opportunity Commission has already ruled that discrimination against transgender people in employment decisions is a form of discrimination based on sex, which is covered under the Civil Rights Act (
http://www.eeoc.gov/federal/otherprotections.cfm).
The key is that a number of counties in Indiana, including Marion County, where Indianapolis is, have passed more comprehensive laws forbidding discrimination in not just employment, but housing and public accomodations (another poster long since has posted an excellent list of what is covered by 'public accomodations', and pretty much all businesses open to the public qualify). *This* is the point of the law -- to deprive LGBT persons the protection of the county law if the person (or entity -- note that the law basically defines 'person' as 'anybody who can be sued') is willing to assert that serving such a person would be a burden on religious belief.
For those who seem to believe that 'the market' will fix this problem all by itself (and ignoring the inconvenient point that, if this were true, why isn't the problem already gone?), it should be noted that a business doesn't need commerce from every person in an area to be successful, just commerce from enough people -- and refusing service to LGBT people is very often a signal allowing other similar-minded people to find and patronize such businesses. This is one way that intolerance persists, because it's profitable.
Lastly, the idea that 'GenCon shouldn't get involved in politics' -- the letter itself speaks to this point. There's already one poster in the thread who has said s/he won't go to GenCon while it's in Indiana and this law is in effect. At least one celebrity, George Takei, is on record as saying he won't serve as a Guest of Honor at conventions in Indiana while the law is in effect, and it's entirely possible that some existing Guests of Honor might withdraw now that the law is signed. This law is already impacting GenCon's ability to organize and present a convention that reaches the largest possible audience of gamers and fans of gaming culture. The folks who run GenCon would be negligent not to consider less problematic alternatives for future conventions, and reminding the governor of that is an entirely reasonable thing for the folks who run GenCon to do. In a sense, it's no different from GenCon sending a letter reminding the mayor of Indianapolis that raising hospitality taxes will have a negative impact on GenCon's bottom line; keeping hospitality taxes low and ensuring access to accomodations to the largest number of gamers are both in GenCon's business interests -- if one is 'political', then both are.
I also want to express my appreciation for the civility and clear-headedness in this discussion thus far. It reflects well on gaming as a whole, and to the community here at ENWorld that we can have this discussion without degenerating into name-calling and slurs.
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Pauper