It certainly is possible. It'll be much different experience, but that comes with both good and bad things. The goal is to take it from a tactical game to a storytelling game, and both have their merits. I think someone could even go so far to say that they use different sides of the brain etc etc...
I'd make it narrative, abstract HP down to healing surges, and go from there. 4E may not be the best system for it, but it certainly can be a breath of fresh air for some.
I'd make it narrative, abstract HP down to healing surges, and go from there. 4E may not be the best system for it, but it certainly can be a breath of fresh air for some.