I'm happy - not because I would run WoD with d20 rules, but because I expect it will provide d20 rules for vampires, werewolves and mages much superior to the current core rules versions. Not that it would be hard to have superior rules, but...
I'm disappointed that it's not d20-Modern-based (i.e., using the Modern generic classes), although conversion between the systems is essentially effortless. Perhaps the werewolves and vampires are 20- (or 25-?) -level racial classes? That would excuse not using the Modern generics.
I'd still use NWoD if I wanted to run a game in the actual WoD setting, but I probably wouldn't buy Monte Cook's WoD if I wanted to do that, anyway.

This is really the only way I'd want to pick it up, and I certainly do.
On the flip side, if, as the cover seems to indicate, this is a post-apocalyptic WoD, perhaps based on characters somehow surviving the apocalypse at the end of the OWoD, that would be pretty cool.