I find it interesting that they're including demons (Demon: the Fallen returns), but not Changelings or Wraiths. Maybe they are in there, and WW just didn't feel they were important enough to advertise their presence.
And regarding the Inconnu, there was that one supplement for Vampire: the Masquerade right before Gehenna (I've forgotten the name, and don't have a copy myself, but had a chance to read through somebody else's) that took the PCs to the home of the Inconnu sect, and revealed there that they apparently worship or are closely tied to a malevolent spirit-being. Now, I think Demon supplements hinted that that was one of the Earthbound, and in the supplement itself it's hinted that it could just be a Methuselah or Antediluvian, but who's to say it wasn't a true Lovecraftian Horror that merely lent its name to the vampire sect? If that's the case, then we have our tie to the old World of Darkness and this truly is a "what comes next" for the setting blown up with the Time of Judgment.
I'll definitely plan to pick up a copy at Gen Con if I can snag one.