My wife tried once. She gave it a good shot but in the end she didn't care for it and for reasons that I didn't expect: she didn't like the discussion and the roleplaying, she just liked to kill things, which isn't the type of game I can run for long.
As for suggestions on how to integrate, start at first level. Craft an engaging first scenario or two. Pay attention to what she seems to respond to and skew the game more that way early on.
I wouldn't bend rules for her but if you find her liking pixies and you allow the group to experience more pixies than you would have otherwise, I doubt your other players would begrudge that much. Getting an SO engaged in a treasured hobby is worth a little accomodation and players likely won't mind you trying to entice her with content. Accomodating by bending rules or throwing loot at her is another matter though.
Also try to pair her up with a player who can coach her. It's hard for the ref to do that and run the game. The most rule savvy person is not necessarily the best coach. Someone who won't irrititate her is the best coach

. Also, you may want to talk to the players who aren't designated the coach and ask them not to help her. Being bombarded by a lot of helpful suggestions from around the gaming table can be both intimidating and annoying.