Hi-
The best plot hook I ran was a ripoff of WFRP's mistaken identity adventure. It's also a great way to get a group of adventures together instead of the old you meet in the inn and the patron offers you a job.
Basically, the players are on a coach heading to a major city when they come upon a group of bandits pilliging an overturned coach. The players fight and destroy the bandits and then proceed to see if anybody is alive.
They then come across an individual that resembles one of the player characters, also upon this person is a note of inheritance which this person is intitled too.
Now, if your players are like most D&D players, they are a greedy treasure seeking lot, so there is a good chance the players will go to the city where the inheritance is at and then try to collect.
But..........
Unkown to the players, the individual that they found is actually or was actually a chaos cultist who was going to the city to collect the inheritance and meet with fellow cultists when he arrived at said city.
There are a couple of ways to mess with the players here, the inheritance note can be real and the players can try and bluff their way into a nice amount of money and of course the Cult also knows about this will come looking for their share
or
The note is fake, a set-up conceived by a bounty hunter to lure the Agent of Chaos out of hiding and now the player has become the target of the bounty hunters attension. AND the Cult also want its cut of the gold.........
So there you have it, an introduction to possibly a globe trotting campaign dealing with cultists and bounty hunters.
Scott